{"id":11035,"date":"2024-01-04T10:51:28","date_gmt":"2024-01-04T08:51:28","guid":{"rendered":"https:\/\/www.cegla.de\/mukoziliaere-clearance"},"modified":"2024-09-30T10:39:23","modified_gmt":"2024-09-30T09:39:23","slug":"mucociliary-clearance","status":"publish","type":"page","link":"https:\/\/www.cegla.de\/en\/mucociliary-clearance\/","title":{"rendered":"Mucociliary clearance"},"content":{"rendered":"

[et_pb_section fb_built=”1″ module_class=”first-section” _builder_version=”4.18.0″ locked=”off” global_colors_info=”{}”][et_pb_row custom_padding_last_edited=”on|desktop” _builder_version=”4.17.6″ _module_preset=”default” background_color=”#FFFFFF” z_index=”3″ width=”100%” width_tablet=”90%” width_phone=”90%” width_last_edited=”on|desktop” max_width=”800px” module_alignment=”center” custom_padding=”30px||0px||false|false” custom_padding_tablet=”30px||||false|false” custom_padding_phone=”||||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” pac_dcm_carousel_specific_module_num=”0″ global_colors_info=”{}”][et_pb_text admin_label=”Post Title” _builder_version=”4.18.0″ link_font=”|600|||||||” header_font=”|600|||||||” header_text_align=”left” header_text_color=”#003E90″ header_font_size=”48px” header_line_height=”1.1em” header_2_line_height=”1.2em” header_3_line_height=”1.2em” custom_margin=”||5px||false|false” header_font_size_tablet=”36px” header_font_size_phone=”28px” header_font_size_last_edited=”on|desktop” header_2_font_size_tablet=”” header_2_font_size_phone=”22px” header_2_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”” header_3_font_size_phone=”18px” header_3_font_size_last_edited=”on|phone” global_colors_info=”%91%93″]<\/p>\n

Mucociliary clearance – the respiratory tract\u2019s self-cleaning mechanism<\/h1>\n

[\/et_pb_text][et_pb_text admin_label=”Post Excerpt” _builder_version=”4.18.0″ text_font_size=”22px” text_line_height=”1.5em” link_font=”|600|||||||” header_font=”||||||||” header_text_align=”left” header_text_color=”#003E90″ header_font_size=”44px” header_line_height=”1.2em” header_2_line_height=”1.2em” header_3_line_height=”1.2em” custom_padding=”||20px||false|false” text_font_size_tablet=”” text_font_size_phone=”18px” text_font_size_last_edited=”on|phone” header_font_size_tablet=”36px” header_font_size_phone=”28px” header_font_size_last_edited=”on|desktop” header_2_font_size_tablet=”” header_2_font_size_phone=”22px” header_2_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”” header_3_font_size_phone=”18px” header_3_font_size_last_edited=”on|phone” global_colors_info=”%91%93″]<\/p>\n

\u201cMucociliary clearance\u201d (MCC) is of critical importance to general respiratory tract health. As a natural defence mechanism for the lungs, it presents as a key component in the complex network of airway physiology. Amid the challenges posed by obstructive respiratory tract diseases, MCC thus becomes the central focus of therapy. We will explain how mucociliary clearance can be preserved and improved \u2013 and lastly, how it helps in the treatment of obstructive airway diseases.<\/p>\n

[\/et_pb_text][et_pb_image src=”https:\/\/www.cegla.de\/wp-content\/uploads\/2024\/01\/roentgenbild-begutachtung.jpg” alt=”Assessment of an X-ray image” _builder_version=”4.18.0″ _module_preset=”default” width=”120%” width_tablet=”120%” width_phone=”” width_last_edited=”on|desktop” custom_margin=”||10px|-10%|false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.18.0″ _module_preset=”default” text_font=”||on||||||” global_colors_info=”{}”]Thanks to mucociliary clearance, particles are loosened and removed from the airways with the assistance of secretion formations. (Agency photo. Prepared with models)<\/span>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ width=”100%” width_tablet=”90%” width_phone=”90%” width_last_edited=”on|desktop” max_width=”800px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ pac_dcm_carousel_specific_module_num=”0″ global_colors_info=”{}”][et_pb_text _builder_version=”4.18.0″ _module_preset=”ec1fce9a-13c1-4a42-ab69-bdb30fb08751″ locked=”off” global_colors_info=”{}”]<\/p>\n

Definition: Mucociliary clearance<\/h2>\n

Mucociliary clearance describes a self-cleaning mechanism of the bronchi<\/strong>. This term stems from both Latin \u2013 \u2018mucus\u2019 for phlegm and \u2018cilia\u2019 for fluttering hair, as well as from English \u2013 \u2018clearance\u2019 for purification or removal1<\/sup>. It bases on the coordinated beating of the cilia<\/strong> \u2013 very fine, hair-like structures on the surface of the epithelial cells in the respiratory tract. Bronchial phlegm, inhaled particles and the entire coating of the surface epithelium<\/strong> are thus continuously mobilised in the direction of the pharynx, where they are transported outside the body<\/strong> with the aid of tussive clearance such as coughing and the sneezing reflex. Thanks to mucociliary clearance, particles are loosened and removed from the respiratory tract with the aid of secretion formations, demonstrating the essential role that it plays in the clearing of the airways<\/strong>2<\/sup>. It consists of a fundamental physiological cascade of defence mechanisms and gains particular importance in the presence of secretion-forming respiratory diseases.<\/p>\n

Mucociliary clearance is not only responsible for continuous clearing of the airways; it also plays a key role in the prevention of acute respiratory tract diseases<\/strong>. Disruptions in this highly-regulated mechanism can result in persistent infections, particularly among patients with previously-existing respiratory tract diseases<\/strong>.<\/p>\n

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Mist inhalation for bolstering mucociliary clearance<\/h2>\n

In order to optimise the efficiency of this helpful system, one must first know the conditions under which optimal mucociliary clearance occurs. A temperature of 37\u00b0C as well as an absolute humidity of 44 mg\/dL, corresponding to a relative humidity of 100%, are required. The effect of even the smallest deviations can be demonstrated on the basis of this example:<\/p>\n

Under the above-mentioned optimal conditions, cilia beat with a frequency of approximately 15 beats per second. For mucokinesis, in this case the transport speed of the mucus, this results in segment advancement of 10-15 mm per minute. If the saturation of the water vapour is below 70%, mucociliary clearance will be heavily restricted \u2013 here, mucokinesis decreases by a factor of 10. This means that at a starting rate of 10 or more mm\/s, particles now move at a rate of only 1 mm\/s. If saturation in the trachea is below 50 percent, this can even result in a disruption of the process, as shown in this video:<\/p>\n

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[\/et_pb_code][et_pb_text _builder_version=”4.18.0″ _module_preset=”ec1fce9a-13c1-4a42-ab69-bdb30fb08751″ custom_margin=”||10px||false|false” global_colors_info=”{}”]Breathing air that is too dry and too cold3<\/sup> can also be responsible for complications, even after one hour of tube ventilation, especially among chronic respiratory patients. These complications include:<\/p>\n